Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Retroviral vectors with long terminal repeats (LTRs), which contain strong enhancer/promoter sequences at both ends of their genome, are widely used for stable gene transfer into hematopoietic cells. However, recent clinical data and mouse models point to insertional activation of cellular proto-onc...

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Bibliografske podrobnosti
Main Authors: Modlich, Ute, Bohne, Jens, Schmidt, Manfred, von Kalle, Christof, Knöss, Sabine, Schambach, Axel, Baum, Christopher
Format: Artigo
Jezik:Inglês
Izdano: © 2006 by The American Society of Hematology 2006
Teme:
Gene Therapy
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895590/
https://ncbi.nlm.nih.gov/pubmed/16825499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-024976
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