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Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found their way into the clinical arena and demonstrated remarkable efficacy for the treatment of immunodeficiencies, leukodystrophies, and globinopathies. Despite these successes, gene therapy unfortunately al...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Biasco, Luca, Rothe, Michael, Büning, Hildegard, Schambach, Axel
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684499/
https://ncbi.nlm.nih.gov/pubmed/29159200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.10.002
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