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Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found their way into the clinical arena and demonstrated remarkable efficacy for the treatment of immunodeficiencies, leukodystrophies, and globinopathies. Despite these successes, gene therapy unfortunately al...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Biasco, Luca, Rothe, Michael, Büning, Hildegard, Schambach, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684499/
https://ncbi.nlm.nih.gov/pubmed/29159200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.10.002
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