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Analyzing the Genotoxicity of Retroviral Vectors in Hematopoietic Cell Gene Therapy

Retroviral vectors, including those derived from gammaretroviruses and lentiviruses, have found their way into the clinical arena and demonstrated remarkable efficacy for the treatment of immunodeficiencies, leukodystrophies, and globinopathies. Despite these successes, gene therapy unfortunately al...

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Publicado en:Mol Ther Methods Clin Dev
Autores principales: Biasco, Luca, Rothe, Michael, Büning, Hildegard, Schambach, Axel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684499/
https://ncbi.nlm.nih.gov/pubmed/29159200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2017.10.002
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