In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Chimeric antigen receptor (CAR) T cells brought substantial benefit to patients with B‐cell malignancies. Notwithstanding, CAR T‐cell manufacturing requires complex procedures impeding the broad supply chain. Here, we provide evidence that human CD19‐CAR T cells can be generated directly in vivo usi...

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Publicado en:EMBO Mol Med
Main Authors: Pfeiffer, Anett, Thalheimer, Frederic B, Hartmann, Sylvia, Frank, Annika M, Bender, Ruben R, Danisch, Simon, Costa, Caroline, Wels, Winfried S, Modlich, Ute, Stripecke, Renata, Verhoeyen, Els, Buchholz, Christian J
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220327/
https://ncbi.nlm.nih.gov/pubmed/30224381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809158
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