Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and deregulation of Thpo/Mpl-signaling is linked to hematological disorders. Here, we constructed an intrac...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Kohlscheen, Saskia, Wintterle, Sabine, Schwarzer, Adrian, Kamp, Christel, Brugman, Martijn H., Breuer, Daniel C., Büsche, Guntram, Baum, Christopher, Modlich, Ute
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4493002/
https://ncbi.nlm.nih.gov/pubmed/26147434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131866
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