Implication for treatment: GABA(A) receptors in aging, Down syndrome and Alzheimer's disease

Por Rissman, Robert A., Mobley, William C.
Publicado em 2011

Intracellular traffic and neurodegenerative disorders

Por St.George-Hyslop, Peter H., Mobley, William C.
Publicado em 2009

A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA

Por Grimes, Mark L., Beattie, Eric, Mobley, William C.
Publicado em 1997

Cognitive and Pharmacological Insights from the Ts65Dn Mouse Model of Down Syndrome

Por Ruparelia, Aarti, Pearn, Matthew L, Mobley, William C
Publicado em 2012

Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome

Por Do, Long H., Mobley, William C., Singhal, Nishant
Publicado no F1000Res (2015)

TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology

Por Miyamoto, Yuki, Yamauchi, Junji, Tanoue, Akito, Wu, Chengbiao, Mobley, William C.
Publicado em 2006

The Coming of Age of Axonal Neurotrophin Signaling Endosomes

Por Wu, Chengbiao, Cui, Bianxiao, He, Lingmin, Chen, Liang, Mobley, William C.
Publicado em 2008

Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease

Por Wagner, Steven L., Tanzi, Rudolph E., Mobley, William C., Galasko, Douglas
Publicado em 2012

Enantioselective Synthesis of (−)-Jiadifenin, a Potent Neurotrophic Modulator

Por Trzoss, Lynnie, Xu, Jing, Lacoske, Michelle H., Mobley, William C., Theodorakis, Emmanuel A.
Publicado em 2011

Illicium Sesquiterpenes: Divergent Synthetic Strategy and Neurotrophic Activity Studies

Por Trzoss, Lynnie, Xu, Jing, Lacoske, Michelle H., Mobley, William C., Theodorakis, Emmanuel A.
Publicado em 2013

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Por Zhao, Xiaobei, Zhou, Yue, Weissmiller, April M., Pearn, Matthew L., Mobley, William C., Wu, Chengbiao
Publicado no J Vis Exp (2014)

The Extracellular Domain of p75(NTR) Is Necessary to Inhibit Neurotrophin-3 Signaling through TrkA

Por Mischel, Paul S., Smith, Shane G., Vining, Ella R., Valletta, Janice S., Mobley, William C., Reichardt, Louis F.
Publicado em 2001

Sleep and EEG features in genetic models of Down syndrome

Por Colas, Damien, Valletta, Janice S., Takimoto-Kimura, Ryoko, Nishino, Seiji, Fujiki, Nobuhiro, Mobley, William C., Mignot, Emmanuel
Publicado no Neurobiol Dis (2007)

Mouse-based genetic modeling and analysis of Down syndrome

Por Xing, Zhuo, Li, Yichen, Pao, Annie, Bennett, Abigail S., Tycko, Benjamin, Mobley, William C., Yu, Y. Eugene
Publicado no Br Med Bull (2016)

The “Down Syndrome Critical Region” Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

Por Belichenko, Nadia P., Belichenko, Pavel V., Kleschevnikov, Alexander M., Salehi, Ahmad, Reeves, Roger H., Mobley, William C.
Publicado em 2009

Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport

Por Liu, Jia-Jia, Ding, Jianqing, Wu, Chengbiao, Bhagavatula, Prasanthi, Cui, Bianxiao, Chu, Steve, Mobley, William C., Yang, Yanmin
Publicado em 2007

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABA(B) Receptor Antagonists

Por Kleschevnikov, Alexander M., Belichenko, Pavel V., Faizi, Mehrdad, Jacobs, Lucia F., Htun, Khin, Shamloo, Mehrdad, Mobley, William C.
Publicado em 2012

Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides

Por Chial, Heidi J., Wu, Ruping, Ustach, Carolyn V., McPhail, Linda C., Mobley, William C., Chen, Yong Q.
Publicado em 2007

Preparation of Primary Neurons for Visualizing Neurites in a Frozen-hydrated State Using Cryo-Electron Tomography

Por Shahmoradian, Sarah H., Galiano, Mauricio R., Wu, Chengbiao, Chen, Shurui, Rasband, Matthew N., Mobley, William C., Chiu, Wah
Publicado em 2014

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Por Kleschevnikov, Alexander M., Yu, Jessica, Kim, Jeesun, Lysenko, Larisa V., Zhen, Zheng, Yu, Y. Eugene, Mobley, William C.
Publicado no Neurobiol Dis (2017)