Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABA(B) Receptor Antagonists

Cognitive impairment in Down syndrome (DS) is characterized by deficient learning and memory. Mouse genetic models of DS exhibit impaired cognition in hippocampally mediated behavioral tasks and reduced synaptic plasticity of hippocampal pathways. Enhanced efficiency of GABAergic neurotransmission w...

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Detalhes bibliográficos
Main Authors: Kleschevnikov, Alexander M., Belichenko, Pavel V., Faizi, Mehrdad, Jacobs, Lucia F., Htun, Khin, Shamloo, Mehrdad, Mobley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411326/
https://ncbi.nlm.nih.gov/pubmed/22764230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1673-12.2012
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