The “Down Syndrome Critical Region” Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

Down syndrome (DS) can be modeled in mice segmentally trisomic for mouse chromosome 16. Ts65Dn and Ts1Cje mouse models have been used to study DS neurobiological phenotypes including changes in cognitive ability, induction of long-term potentiation (LTP) in the fascia dentata (FD), the density and s...

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Main Authors: Belichenko, Nadia P., Belichenko, Pavel V., Kleschevnikov, Alexander M., Salehi, Ahmad, Reeves, Roger H., Mobley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849469/
https://ncbi.nlm.nih.gov/pubmed/19420260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1547-09.2009
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