The “Down Syndrome Critical Region” Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

Down syndrome (DS) can be modeled in mice segmentally trisomic for mouse chromosome 16. Ts65Dn and Ts1Cje mouse models have been used to study DS neurobiological phenotypes including changes in cognitive ability, induction of long-term potentiation (LTP) in the fascia dentata (FD), the density and s...

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Hlavní autoři: Belichenko, Nadia P., Belichenko, Pavel V., Kleschevnikov, Alexander M., Salehi, Ahmad, Reeves, Roger H., Mobley, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849469/
https://ncbi.nlm.nih.gov/pubmed/19420260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1547-09.2009
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