The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca(2+) dynamics in adult mice

Por Mitchell, Ryan K., Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Callingham, Rebecca M., Pullen, Timothy J., Cheung, Rebecca, Leclerc, Isabelle, Hodson, David J., Rutter, Guy A.
Publicado no J Biol Chem (2017)

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

Por Mitchell, Ryan K., Mondragon, Angeles, Chen, Lingling, Mcginty, James A., French, Paul M., Ferrer, Jorge, Thorens, Bernard, Hodson, David J., Rutter, Guy A., Da Silva Xavier, Gabriela
Publicado no Hum Mol Genet (2015)

Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

Por Mitchell, Ryan K., Hu, Ming, Chabosseau, Pauline L., Cane, Matthew C., Meur, Gargi, Bellomo, Elisa A., Carzaniga, Raffaella, Collinson, Lucy M., Li, Wen-Hong, Hodson, David J., Rutter, Guy A.
Publicado no Mol Endocrinol (2016)

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

Por Gerber, Philipp A., Bellomo, Elisa A., Hodson, David J., Meur, Gargi, Solomou, Antonia, Mitchell, Ryan K., Hollinshead, Michael, Chimienti, Fabrice, Bosco, Domenico, Hughes, Stephen J., Johnson, Paul R. V., Rutter, Guy A.
Publicado em 2014

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans

Por Hodson, David J., Tarasov, Andrei I., Gimeno Brias, Silvia, Mitchell, Ryan K., Johnston, Natalie R., Haghollahi, Shahab, Cane, Matthew C., Bugliani, Marco, Marchetti, Piero, Bosco, Domenico, Johnson, Paul R., Hughes, Stephen J., Rutter, Guy A.
Publicado em 2014

Lipotoxicity disrupts incretin-regulated human β cell connectivity

Por Hodson, David J., Mitchell, Ryan K., Bellomo, Elisa A., Sun, Gao, Vinet, Laurent, Meda, Paolo, Li, Daliang, Li, Wen-Hong, Bugliani, Marco, Marchetti, Piero, Bosco, Domenico, Piemonti, Lorenzo, Johnson, Paul, Hughes, Stephen J., Rutter, Guy A.
Publicado no J Clin Invest (2013)

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Por Johnston, Natalie R., Mitchell, Ryan K., Haythorne, Elizabeth, Pessoa, Maria Paiva, Semplici, Francesca, Ferrer, Jorge, Piemonti, Lorenzo, Marchetti, Piero, Bugliani, Marco, Bosco, Domenico, Berishvili, Ekaterine, Duncanson, Philip, Watkinson, Michael, Broichhagen, Johannes, Trauner, Dirk, Rutter, Guy A., Hodson, David J.
Publicado no Cell Metab (2016)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

Por Hodson, David J., Mitchell, Ryan K., Marselli, Lorella, Pullen, Timothy J., Gimeno Brias, Silvia, Semplici, Francesca, Everett, Katy L., Cooper, Dermot M.F., Bugliani, Marco, Marchetti, Piero, Lavallard, Vanessa, Bosco, Domenico, Piemonti, Lorenzo, Johnson, Paul R., Hughes, Stephen J., Li, Daliang, Li, Wen-Hong, Shapiro, A.M. James, Rutter, Guy A.
Publicado em 2014