ADCY5 Couples Glucose to Insulin Secretion in Human Islets

Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2 diabetes (T2D) risk. Despite this, the mechanisms underlying the effects of these polymorphic variants at the level of pancreatic β-cells rema...

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Detalhes bibliográficos
Main Authors: Hodson, David J., Mitchell, Ryan K., Marselli, Lorella, Pullen, Timothy J., Gimeno Brias, Silvia, Semplici, Francesca, Everett, Katy L., Cooper, Dermot M.F., Bugliani, Marco, Marchetti, Piero, Lavallard, Vanessa, Bosco, Domenico, Piemonti, Lorenzo, Johnson, Paul R., Hughes, Stephen J., Li, Daliang, Li, Wen-Hong, Shapiro, A.M. James, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2014
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141364/
https://ncbi.nlm.nih.gov/pubmed/24740569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1607
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