Development of NanoART for HIV Treatment: Minding the Cytochrome P450 (CYP) Enzymes

gan Midde, Narasimha M., Kumar, Santosh
Cyhoeddwyd yn J Pers Nanomed (2015)

HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes

gan Midde, Narasimha M., Gomez, Adrian M., Zhu, Jun
Cyhoeddwyd 2012

Investigational reverse transcriptase inhibitors for the treatment of HIV

gan Cory, Theodore J, Midde, Narasimha M, Rao, PSS, Kumar, Santosh
Cyhoeddwyd yn Expert Opin Investig Drugs (2015)

Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats

gan Midde, Narasimha M., Gomez, Adrian M., Harrod, Steven B., Zhu, Jun
Cyhoeddwyd 2011

Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells

gan Midde, Narasimha M., Sinha, Namita, Lukka, Pradeep B., Meibohm, Bernd, Kumar, Santosh
Cyhoeddwyd yn PLoS One (2017)

Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors

gan Rahman, Mohammad A., Midde, Narasimha M., Wu, Xiaoxin, Li, Wei, Kumar, Santosh
Cyhoeddwyd yn Pharmacol Res Perspect (2017)

Investigational protease inhibitors as antiretroviral therapies

gan Midde, Narasimha M., Patters, Benjamin J., Rao, PSS, Cory, Theodore J., Kumar, Santosh
Cyhoeddwyd yn Expert Opin Investig Drugs (2016)

Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication

gan Haque, Sanjana, Sinha, Namita, Ranjit, Sabina, Midde, Narasimha M., Kashanchi, Fatah, Kumar, Santosh
Cyhoeddwyd yn Sci Rep (2017)

Environmental Enrichment Alters Nicotine-Mediated Locomotor Sensitization and Phosphorylation of DARPP-32 and CREB in Rat Prefrontal Cortex

gan Gomez, Adrian M., Midde, Narasimha M., Mactutus, Charles F., Booze, Rosemarie M., Zhu, Jun
Cyhoeddwyd 2012

Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration

gan Gomez, Adrian M., Sun, Wei-Lun, Midde, Narasimha M., Harrod, Steven B., Zhu, Jun
Cyhoeddwyd yn Eur J Neurosci (2014)

Intra-ventral tegmental area HIV-1 Tat(1–86) attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

gan Zhu, Jun, Midde, Narasimha M., Gomez, Adrian M., Sun, Wei-Lun, Harrod, Steven B.
Cyhoeddwyd yn Front Microbiol (2015)

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

gan Rao, PSS, Midde, Narasimha M, Miller, Duane D., Chauhan, Subhash, Kumar, Anil, Kumar, Santosh
Cyhoeddwyd yn Curr Drug Metab (2015)

Novel elvitegravir nanoformulation approach to suppress the viral load in HIV-infected macrophages

gan Gong, Yuqing, Chowdhury, Pallabita, Midde, Narasimha M., Rahman, Mohammad A., Yallapu, Murali M., Kumar, Santosh
Cyhoeddwyd yn Biochem Biophys Rep (2017)

Tobacco and Antiretrovirals Modulate Transporter, Metabolic Enzyme, and Antioxidant Enzyme Expression and Function in Polarized Macrophages

gan Mu, Ying, Patters, Benjamin J., Midde, Narasimha M., He, Hui, Kumar, Santosh, Cory, Theodore J.
Cyhoeddwyd yn Curr HIV Res (2018)

Mutation of Tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions

gan Midde, Narasimha M., Huang, Xiaoqin, Gomez, Adrian M., Booze, Rosemarie M., Zhan, Chang-Guo, Zhu, Jun
Cyhoeddwyd 2013

Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Me...

gan Midde, Narasimha M., Rahman, Mohammad A., Rathi, Chetan, Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Cyhoeddwyd yn PLoS One (2016)

Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport

gan Quizon, Pamela M., Sun, Wei-Lun, Yuan, Yaxia, Midde, Narasimha M., Zhan, Chang-Guo, Zhu, Jun
Cyhoeddwyd yn Sci Rep (2016)

Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Stud...

gan Midde, Narasimha M., Gong, Yuqing, Cory, Theodore J., Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Cyhoeddwyd yn Pharm Res (2017)

Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications

gan Kumar, Santosh, Sinha, Namita, Gerth, Kelli A., Rahman, Mohammad A., Yallapu, Murali M., Midde, Narasimha M.
Cyhoeddwyd yn Biochem Biophys Res Commun (2017)

Mutations at Tyrosine 88, Lysine 92 and Tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport

gan Midde, Narasimha M., Yuan, Yaxia, Quizon, Pamela M., Sun, Wei-Lun, Huang, Xiaoqin, Zhan, Chang-Guo, Zhu, Jun
Cyhoeddwyd yn J Neuroimmune Pharmacol (2015)