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Mutation of Tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions

HIV-1 Tat protein plays a crucial role in perturbations of the dopamine (DA) system. Our previous studies have demonstrated that Tat decreases DA uptake, and allosterically modulates DA transporter (DAT) function. In the present study, we have found that Tat interacts directly with DAT, leading to i...

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書誌詳細
主要な著者: Midde, Narasimha M., Huang, Xiaoqin, Gomez, Adrian M., Booze, Rosemarie M., Zhan, Chang-Guo, Zhu, Jun
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740080/
https://ncbi.nlm.nih.gov/pubmed/23645138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-013-9464-6
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