Development of NanoART for HIV Treatment: Minding the Cytochrome P450 (CYP) Enzymes

Por Midde, Narasimha M., Kumar, Santosh
Publicado no J Pers Nanomed (2015)

HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes

Por Midde, Narasimha M., Gomez, Adrian M., Zhu, Jun
Publicado em 2012

Investigational reverse transcriptase inhibitors for the treatment of HIV

Por Cory, Theodore J, Midde, Narasimha M, Rao, PSS, Kumar, Santosh
Publicado no Expert Opin Investig Drugs (2015)

Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats

Por Midde, Narasimha M., Gomez, Adrian M., Harrod, Steven B., Zhu, Jun
Publicado em 2011

Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells

Por Midde, Narasimha M., Sinha, Namita, Lukka, Pradeep B., Meibohm, Bernd, Kumar, Santosh
Publicado no PLoS One (2017)

Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors

Por Rahman, Mohammad A., Midde, Narasimha M., Wu, Xiaoxin, Li, Wei, Kumar, Santosh
Publicado no Pharmacol Res Perspect (2017)

Investigational protease inhibitors as antiretroviral therapies

Por Midde, Narasimha M., Patters, Benjamin J., Rao, PSS, Cory, Theodore J., Kumar, Santosh
Publicado no Expert Opin Investig Drugs (2016)

Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication

Por Haque, Sanjana, Sinha, Namita, Ranjit, Sabina, Midde, Narasimha M., Kashanchi, Fatah, Kumar, Santosh
Publicado no Sci Rep (2017)

Environmental Enrichment Alters Nicotine-Mediated Locomotor Sensitization and Phosphorylation of DARPP-32 and CREB in Rat Prefrontal Cortex

Por Gomez, Adrian M., Midde, Narasimha M., Mactutus, Charles F., Booze, Rosemarie M., Zhu, Jun
Publicado em 2012

Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration

Por Gomez, Adrian M., Sun, Wei-Lun, Midde, Narasimha M., Harrod, Steven B., Zhu, Jun
Publicado no Eur J Neurosci (2014)

Intra-ventral tegmental area HIV-1 Tat(1–86) attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

Por Zhu, Jun, Midde, Narasimha M., Gomez, Adrian M., Sun, Wei-Lun, Harrod, Steven B.
Publicado no Front Microbiol (2015)

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

Por Rao, PSS, Midde, Narasimha M, Miller, Duane D., Chauhan, Subhash, Kumar, Anil, Kumar, Santosh
Publicado no Curr Drug Metab (2015)

Novel elvitegravir nanoformulation approach to suppress the viral load in HIV-infected macrophages

Por Gong, Yuqing, Chowdhury, Pallabita, Midde, Narasimha M., Rahman, Mohammad A., Yallapu, Murali M., Kumar, Santosh
Publicado no Biochem Biophys Rep (2017)

Tobacco and Antiretrovirals Modulate Transporter, Metabolic Enzyme, and Antioxidant Enzyme Expression and Function in Polarized Macrophages

Por Mu, Ying, Patters, Benjamin J., Midde, Narasimha M., He, Hui, Kumar, Santosh, Cory, Theodore J.
Publicado no Curr HIV Res (2018)

Mutation of Tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions

Por Midde, Narasimha M., Huang, Xiaoqin, Gomez, Adrian M., Booze, Rosemarie M., Zhan, Chang-Guo, Zhu, Jun
Publicado em 2013

Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Me...

Por Midde, Narasimha M., Rahman, Mohammad A., Rathi, Chetan, Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Publicado no PLoS One (2016)

Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport

Por Quizon, Pamela M., Sun, Wei-Lun, Yuan, Yaxia, Midde, Narasimha M., Zhan, Chang-Guo, Zhu, Jun
Publicado no Sci Rep (2016)

Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Stud...

Por Midde, Narasimha M., Gong, Yuqing, Cory, Theodore J., Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Publicado no Pharm Res (2017)

Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications

Por Kumar, Santosh, Sinha, Namita, Gerth, Kelli A., Rahman, Mohammad A., Yallapu, Murali M., Midde, Narasimha M.
Publicado no Biochem Biophys Res Commun (2017)

Mutations at Tyrosine 88, Lysine 92 and Tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport

Por Midde, Narasimha M., Yuan, Yaxia, Quizon, Pamela M., Sun, Wei-Lun, Huang, Xiaoqin, Zhan, Chang-Guo, Zhu, Jun
Publicado no J Neuroimmune Pharmacol (2015)