Development of NanoART for HIV Treatment: Minding the Cytochrome P450 (CYP) Enzymes

per Midde, Narasimha M., Kumar, Santosh
Publicat a J Pers Nanomed (2015)

HIV-1 Tat protein decreases dopamine transporter cell surface expression and vesicular monoamine transporter-2 function in rat striatal synaptosomes

per Midde, Narasimha M., Gomez, Adrian M., Zhu, Jun
Publicat 2012

Investigational reverse transcriptase inhibitors for the treatment of HIV

per Cory, Theodore J, Midde, Narasimha M, Rao, PSS, Kumar, Santosh
Publicat a Expert Opin Investig Drugs (2015)

Genetically expressed HIV-1 viral proteins attenuate nicotine-induced behavioral sensitization and alter mesocorticolimbic ERK and CREB signaling in rats

per Midde, Narasimha M., Gomez, Adrian M., Harrod, Steven B., Zhu, Jun
Publicat 2011

Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells

per Midde, Narasimha M., Sinha, Namita, Lukka, Pradeep B., Meibohm, Bernd, Kumar, Santosh
Publicat a PLoS One (2017)

Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors

per Rahman, Mohammad A., Midde, Narasimha M., Wu, Xiaoxin, Li, Wei, Kumar, Santosh
Publicat a Pharmacol Res Perspect (2017)

Investigational protease inhibitors as antiretroviral therapies

per Midde, Narasimha M., Patters, Benjamin J., Rao, PSS, Cory, Theodore J., Kumar, Santosh
Publicat a Expert Opin Investig Drugs (2016)

Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication

per Haque, Sanjana, Sinha, Namita, Ranjit, Sabina, Midde, Narasimha M., Kashanchi, Fatah, Kumar, Santosh
Publicat a Sci Rep (2017)

Environmental Enrichment Alters Nicotine-Mediated Locomotor Sensitization and Phosphorylation of DARPP-32 and CREB in Rat Prefrontal Cortex

per Gomez, Adrian M., Midde, Narasimha M., Mactutus, Charles F., Booze, Rosemarie M., Zhu, Jun
Publicat 2012

Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration

per Gomez, Adrian M., Sun, Wei-Lun, Midde, Narasimha M., Harrod, Steven B., Zhu, Jun
Publicat a Eur J Neurosci (2014)

Intra-ventral tegmental area HIV-1 Tat(1–86) attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

per Zhu, Jun, Midde, Narasimha M., Gomez, Adrian M., Sun, Wei-Lun, Harrod, Steven B.
Publicat a Front Microbiol (2015)

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

per Rao, PSS, Midde, Narasimha M, Miller, Duane D., Chauhan, Subhash, Kumar, Anil, Kumar, Santosh
Publicat a Curr Drug Metab (2015)

Novel elvitegravir nanoformulation approach to suppress the viral load in HIV-infected macrophages

per Gong, Yuqing, Chowdhury, Pallabita, Midde, Narasimha M., Rahman, Mohammad A., Yallapu, Murali M., Kumar, Santosh
Publicat a Biochem Biophys Rep (2017)

Tobacco and Antiretrovirals Modulate Transporter, Metabolic Enzyme, and Antioxidant Enzyme Expression and Function in Polarized Macrophages

per Mu, Ying, Patters, Benjamin J., Midde, Narasimha M., He, Hui, Kumar, Santosh, Cory, Theodore J.
Publicat a Curr HIV Res (2018)

Mutation of Tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions

per Midde, Narasimha M., Huang, Xiaoqin, Gomez, Adrian M., Booze, Rosemarie M., Zhan, Chang-Guo, Zhu, Jun
Publicat 2013

Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Me...

per Midde, Narasimha M., Rahman, Mohammad A., Rathi, Chetan, Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Publicat a PLoS One (2016)

Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport

per Quizon, Pamela M., Sun, Wei-Lun, Yuan, Yaxia, Midde, Narasimha M., Zhan, Chang-Guo, Zhu, Jun
Publicat a Sci Rep (2016)

Influence of Ethanol on Darunavir Hepatic Clearance and Intracellular PK/PD in HIV-Infected Monocytes, and CYP3A4-Darunavir Interactions Using Inhibition and in Silico Binding Stud...

per Midde, Narasimha M., Gong, Yuqing, Cory, Theodore J., Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Publicat a Pharm Res (2017)

Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications

per Kumar, Santosh, Sinha, Namita, Gerth, Kelli A., Rahman, Mohammad A., Yallapu, Murali M., Midde, Narasimha M.
Publicat a Biochem Biophys Res Commun (2017)

Mutations at Tyrosine 88, Lysine 92 and Tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport

per Midde, Narasimha M., Yuan, Yaxia, Quizon, Pamela M., Sun, Wei-Lun, Huang, Xiaoqin, Zhan, Chang-Guo, Zhu, Jun
Publicat a J Neuroimmune Pharmacol (2015)