Utility of different massive parallel sequencing platforms for mutation profiling in clinical samples and identification of pitfalls using FFPE tissue

Por FASSUNKE, JANA, HALLER, FLORIAN, HEBELE, SIMONE, MOSKALEV, EVGENY A., PENZEL, ROLAND, PFARR, NICOLE, MERKELBACH-BRUSE, SABINE, ENDRIS, VOLKER
Publicado no Int J Mol Med (2015)

Association of Platelet-Derived Growth Factor Receptor α Mutations with Gastric Primary Site and Epithelioid or Mixed Cell Morphology in Gastrointestinal Stromal Tumors

Por Wardelmann, Eva, Hrychyk, Aksana, Merkelbach-Bruse, Sabine, Pauls, Katharina, Goldstein, Jennifer, Hohenberger, Peter, Losen, Inge, Manegold, Christoph, Büttner, Reinhard, Pietsch, Torsten
Publicado em 2004

qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AX...

Por Fassunke, Jana, Blum, Marie-Christine, Schildhaus, Hans-Ulrich, Zapatka, Marc, Brors, Benedikt, Künstlinger, Helen, Büttner, Reinhard, Wardelmann, Eva, Merkelbach-Bruse, Sabine
Publicado em 2010

c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia

Por Kübler, Kirsten, Heinenberg, Sally, Rudlowski, Christian, Keyver-Paik, Mignon-Denise, Abramian, Alina, Merkelbach-Bruse, Sabine, Büttner, Reinhard, Kuhn, Walther, Schildhaus, Hans-Ulrich
Publicado no Oncotarget (2014)

Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E a...

Por Ihle, Michaela Angelika, Fassunke, Jana, König, Katharina, Grünewald, Inga, Schlaak, Max, Kreuzberg, Nicole, Tietze, Lothar, Schildhaus, Hans-Ulrich, Büttner, Reinhard, Merkelbach-Bruse, Sabine
Publicado em 2014

FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro

Por Künstlinger, Helen, Fassunke, Jana, Schildhaus, Hans-Ulrich, Brors, Benedikt, Heydt, Carina, Ihle, Michaela Angelika, Mechtersheimer, Gunhild, Wardelmann, Eva, Büttner, Reinhard, Merkelbach-Bruse, Sabine
Publicado no Oncotarget (2015)

Comparison of Pre-Analytical FFPE Sample Preparation Methods and Their Impact on Massively Parallel Sequencing in Routine Diagnostics

Por Heydt, Carina, Fassunke, Jana, Künstlinger, Helen, Ihle, Michaela Angelika, König, Katharina, Heukamp, Lukas Carl, Schildhaus, Hans-Ulrich, Odenthal, Margarete, Büttner, Reinhard, Merkelbach-Bruse, Sabine
Publicado em 2014

A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del)

Por Huss, Sebastian, Künstlinger, Helen, Wardelmann, Eva, Kleine, Michaela A, Binot, Elke, Merkelbach-Bruse, Sabine, Rüdiger, Thomas, Mittler, Jens, Hartmann, Wolfgang, Büttner, Reinhard, Schildhaus, Hans-Ulrich
Publicado em 2013

MET Gene Copy Number Alterations and Expression of MET and Hepatocyte Growth Factor Are Potential Biomarkers in Angiosarcomas and Undifferentiated Pleomorphic Sarcomas

Por Schmitz, Katja, Koeppen, Hartmut, Binot, Elke, Fassunke, Jana, Künstlinger, Helen, Ihle, Michaela A., Heydt, Carina, Wardelmann, Eva, Büttner, Reinhard, Merkelbach-Bruse, Sabine, Rüschoff, Josef, Schildhaus, Hans-Ulrich
Publicado no PLoS One (2015)

Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

Por Heydt, Carina, Kumm, Niklas, Fassunke, Jana, Künstlinger, Helen, Ihle, Michaela Angelika, Scheel, Andreas, Schildhaus, Hans-Ulrich, Haller, Florian, Büttner, Reinhard, Odenthal, Margarete, Wardelmann, Eva, Merkelbach-Bruse, Sabine
Publicado no BMC Cancer (2015)

Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors

Por Merkelbach-Bruse, Sabine, Dietmaier, Wolfgang, Füzesi, Laszlo, Gaumann, Andreas, Haller, Florian, Kitz, Julia, Krohn, Antje, Mechtersheimer, Gunhild, Penzel, Roland, Schildhaus, Hans-Ulrich, Schneider-Stock, Regine, Simon, Ronald, Wardelmann, Eva
Publicado em 2010

HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat

Por Angelika Ihle, Michaela, Merkelbach‐Bruse, Sabine, Hartmann, Wolfgang, Bauer, Sebastian, Ratner, Nancy, Sonobe, Hiroshi, Nishio, Jun, Larsson, Olle, Åman, Pierre, Pedeutour, Florence, Taguchi, Takahiro, Wardelmann, Eva, Buettner, Reinhard, Schildhaus, Hans‐Ulrich
Publicado no J Pathol Clin Res (2016)

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

Por Meder, Lydia, König, Katharina, Ozretić, Luka, Schultheis, Anne M., Ueckeroth, Frank, Ade, Carsten P., Albus, Kerstin, Boehm, Diana, Rommerscheidt‐Fuss, Ursula, Florin, Alexandra, Buhl, Theresa, Hartmann, Wolfgang, Wolf, Jürgen, Merkelbach‐Bruse, Sabine, Eilers, Martin, Perner, Sven, Heukamp, Lukas C., Buettner, Reinhard
Publicado no Int J Cancer (2015)

ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability

Por Scheffler, Matthias, Schultheis, Anne, Teixido, Cristina, Michels, Sebastian, Morales-Espinosa, Daniela, Viteri, Santiago, Hartmann, Wolfgang, Merkelbach-Bruse, Sabine, Fischer, Rieke, Schildhaus, Hans-Ulrich, Fassunke, Jana, Sebastian, Martin, Serke, Monika, Kaminsky, Britta, Randerath, Winfried, Gerigk, Ulrich, Ko, Yon-Dschun, Krüger, Stefan, Schnell, Roland, Rothe, Achim, Kropf-Sanchen, Cornelia, Heukamp, Lukas, Rosell, Rafael, Büttner, Reinhard, Wolf, Jürgen
Publicado no Oncotarget (2015)

PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies

Por Scheffler, Matthias, Bos, Marc, Gardizi, Masyar, König, Katharina, Michels, Sebastian, Fassunke, Jana, Heydt, Carina, Künstlinger, Helen, Ihle, Michaela, Ueckeroth, Frank, Albus, Kerstin, Serke, Monika, Gerigk, Ulrich, Schulte, Wolfgang, Töpelt, Karin, Nogova, Lucia, Zander, Thomas, Engel-Riedel, Walburga, Stoelben, Erich, Ko, Yon-Dschun, Randerath, Winfried, Kaminsky, Britta, Panse, Jens, Becker, Carolin, Hellmich, Martin, Merkelbach-Bruse, Sabine, Heukamp, Lukas C., Büttner, Reinhard, Wolf, Jürgen
Publicado no Oncotarget (2014)

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

Por Schildhaus, Hans-Ulrich, Heukamp, Lukas C, Merkelbach-Bruse, Sabine, Riesner, Katharina, Schmitz, Katja, Binot, Elke, Paggen, Ellen, Albus, Kerstin, Schulte, Wolfgang, Ko, Yon-Dschun, Schlesinger, Andreas, Ansén, Sascha, Engel-Riedel, Walburga, Brockmann, Michael, Serke, Monika, Gerigk, Ulrich, Huss, Sebastian, Göke, Friederike, Perner, Sven, Hekmat, Khosro, Frank, Konrad F, Reiser, Marcel, Schnell, Roland, Bos, Marc, Mattonet, Christian, Sos, Martin, Stoelben, Erich, Wolf, Jürgen, Zander, Thomas, Buettner, Reinhard
Publicado em 2012