A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del)

About 10–15% of gastrointestinal stromal tumors (GISTs) carry wild-type sequences in all hot spots of KIT and platelet-derived growth factor receptor alpha (PDGFRA) (wt-GISTs). These tumors are currently defined by having no mutations in exons 9, 11, 13, and 17 of the KIT gene and exons 12, 14, and...

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Detalhes bibliográficos
Main Authors: Huss, Sebastian, Künstlinger, Helen, Wardelmann, Eva, Kleine, Michaela A, Binot, Elke, Merkelbach-Bruse, Sabine, Rüdiger, Thomas, Mittler, Jens, Hartmann, Wolfgang, Büttner, Reinhard, Schildhaus, Hans-Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701292/
https://ncbi.nlm.nih.gov/pubmed/23599150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2013.47
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