Imatinib Responsiveness in Canine Mast Cell Tumors Carrying Novel Mutations of c-KIT Exon 11

In 2 individual cases of canine mast cell tumors, we identified 2 novel c-KIT mutations in exon 11: a 9-base pair (bp) deletion (c.1663-1671del) and a point mutation (c.1676T>A). The 9-bp deletion mutation caused a loss of 3 amino acids, corresponding to p.Gln555_Lys557del, and the point mutation...

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Bibliografiske detaljer
Main Authors: NAKANO, Yuko, KOBAYASHI, Tetsuya, OSHIMA, Fukiko, FUKAZAWA, Eri, YAMAGAMI, Tetsushi, SHIRAISHI, Yozo, TAKANOSU, Masamine
Format: Artigo
Sprog:Inglês
Udgivet: The Japanese Society of Veterinary Science 2013
Fag:
Internal Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064139/
https://ncbi.nlm.nih.gov/pubmed/24292246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.13-0156
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