Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H

BACKGROUND: Acquired resistance to imatinib is frequently caused by secondary KIT mutations. We have investigated the effects of imatinib in mice with human gastrointestinal stromal tumour (GIST) xenograft which harbours a primary exon 11 deletion mutation and a secondary imatinib resistance mutatio...

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Hlavní autoři: Revheim, Mona-Elisabeth, Kristian, Alexandr, Malinen, Eirik, Bruland, Øyvind Sverre, Berner, Jeanne-Marie, Holm, Ruth, Joensuu, Heikki, Seierstad, Therese
Médium: Artigo
Jazyk:Inglês
Vydáno: Informa Healthcare 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622233/
https://ncbi.nlm.nih.gov/pubmed/23480638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/0284186X.2013.770920
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