Prognosis and predictive value of KIT exon 11 deletion in GISTs

BACKGROUND: KIT exon 11 mutations are observed in 60% of gastrointestinal stromal tumours (GIST). Exon 11 codes for residues Tyr568 and Tyr570, which play a major role in signal transduction and degradation of KIT. Our aim was to compare the outcome of patients with deletion of both Tyr568–570 (delT...

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Detalhes bibliográficos
Main Authors: Bachet, J-B, Hostein, I, Le Cesne, A, Brahimi, S, Beauchet, A, Tabone-Eglinger, S, Subra, F, Bui, B, Duffaud, F, Terrier, P, Coindre, J-M, Blay, J-Y, Emile, J-F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713701/
https://ncbi.nlm.nih.gov/pubmed/19536093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605117
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