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Effects of endoplasmic reticulum stressors on maturation and signaling of hemizygous and heterozygous wild‐type and mutant forms of KIT
Gain of function mutations of KIT are frequent in some human tumors, and are sensible to tyrosine kinase inhibitors. In most tumors, oncogenic mutations are heterozygous, however most in vitro data of KIT activation have been obtained with hemizygous mutation. This study aimed to investigate the mat...
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| 出版年: | Mol Oncol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
John Wiley and Sons Inc.
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5528484/ https://ncbi.nlm.nih.gov/pubmed/23146721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.10.008 |
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