Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

BACKGROUND: Personalised medicine and targeted therapy have revolutionised cancer treatment. However, most patients develop drug resistance and relapse after showing an initial treatment response. Two theories have been postulated; either secondary resistance mutations develop de novo during therapy...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Heydt, Carina, Kumm, Niklas, Fassunke, Jana, Künstlinger, Helen, Ihle, Michaela Angelika, Scheel, Andreas, Schildhaus, Hans-Ulrich, Haller, Florian, Büttner, Reinhard, Odenthal, Margarete, Wardelmann, Eva, Merkelbach-Bruse, Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404105/
https://ncbi.nlm.nih.gov/pubmed/25886408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1311-0
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