NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated...

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Detalles Bibliográficos
Publicado en:Int J Cancer
Main Authors: Meder, Lydia, König, Katharina, Ozretić, Luka, Schultheis, Anne M., Ueckeroth, Frank, Ade, Carsten P., Albus, Kerstin, Boehm, Diana, Rommerscheidt‐Fuss, Ursula, Florin, Alexandra, Buhl, Theresa, Hartmann, Wolfgang, Wolf, Jürgen, Merkelbach‐Bruse, Sabine, Eilers, Martin, Perner, Sven, Heukamp, Lukas C., Buettner, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2015
Assuntos:
Molecular Cancer Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832386/
https://ncbi.nlm.nih.gov/pubmed/26340530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29835
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