NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas

Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated...

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Bibliografiske detaljer
Udgivet i:Int J Cancer
Main Authors: Meder, Lydia, König, Katharina, Ozretić, Luka, Schultheis, Anne M., Ueckeroth, Frank, Ade, Carsten P., Albus, Kerstin, Boehm, Diana, Rommerscheidt‐Fuss, Ursula, Florin, Alexandra, Buhl, Theresa, Hartmann, Wolfgang, Wolf, Jürgen, Merkelbach‐Bruse, Sabine, Eilers, Martin, Perner, Sven, Heukamp, Lukas C., Buettner, Reinhard
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Molecular Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832386/
https://ncbi.nlm.nih.gov/pubmed/26340530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29835
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