Loss of the Keratin Cytoskeleton Is Not Sufficient to Induce Epithelial Mesenchymal Transition in a Novel KRAS Driven Sporadic Lung Cancer Mouse Model

Epithelial-to-mesenchymal transition (EMT), the phenotypical change of cells from an epithelial to a mesenchymal type, is thought to be a key event in invasion and metastasis of adenocarcinomas. These changes involve loss of keratin expression as well as loss of cell polarity and adhesion. We here a...

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Main Authors: König, Katharina, Meder, Lydia, Kröger, Cornelia, Diehl, Linda, Florin, Alexandra, Rommerscheidt-Fuss, Ursula, Kahl, Philip, Wardelmann, Eva, Magin, Thomas M., Buettner, Reinhard, Heukamp, Lukas C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594220/
https://ncbi.nlm.nih.gov/pubmed/23536778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057996
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