Drug targets in kinetoplastid parasites

Por Majumder, Hemanta K.
Publicado em 2008

Identification of a Functional Type IA Topoisomerase, LdTopIIIβ, from Kinetoplastid Parasite Leishmania donovani

Por Banerjee, Bijoylaxmi, Sen, Nilkantha, Majumder, Hemanta K.
Publicado em 2011

Target Identification and Intervention Strategies against Kinetoplastid Protozoan Parasites

Por Majumder, Hemanta K., de Souza, Wanderley, Chang, Kwang Poo
Publicado em 2011

An insight into the active site of a type I DNA topoisomerase from the kinetoplastid protozoan Leishmania donovani

Por Das, Aditi, Mandal, Chhabinath, Dasgupta, Arindam, Sengupta, Tanushri, Majumder, Hemanta K.
Publicado em 2002

Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani

Por Sengupta, Tanushri, Mukherjee, Mandira, Mandal, Chhabinath, Das, Aditi, Majumder, Hemanta K.
Publicado em 2003

Characterization of the DNA-binding domain and identification of the active site residue in the ‘Gyr A’ half of Leishmania donovani topoisomerase II

Por Sengupta, Tanushri, Mukherjee, Mandira, Das, Rakhee, Das, Aditi, Majumder, Hemanta K.
Publicado em 2005

Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani tow...

Por Roy, Amit, BoseDasgupta, Somdeb, Ganguly, Agneyo, Jaisankar, Parasuraman, Majumder, Hemanta K.
Publicado em 2009

Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy

Por Sengupta, Souvik, Chowdhury, Sayan, BoseDasgupta, Somdeb, Wright, Colin W., Majumder, Hemanta K.
Publicado em 2011

Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.

Por Chowdhury, Arnab Roy, Sharma, Shalini, Mandal, Suparna, Goswami, Anindya, Mukhopadhyay, Sibabrata, Majumder, Hemanta K
Publicado em 2002

Characterisation of the gene encoding type II DNA topoisomerase from Leishmania donovani: a key molecular target in antileishmanial therapy

Por Das, Aditi, Dasgupta, Arindam, Sharma, Shalini, Ghosh, Monidipa, Sengupta, Tanushri, Bandopadhyay, Santu, Majumder, Hemanta K.
Publicado em 2001

Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide

Por Sengupta, Tanushri, Mukherjee, Mandira, Das, Aditi, Mandal, Chhabinath, Das, Rakhee, Mukherjee, Tanmoy, Majumder, Hemanta K.
Publicado em 2005

‘LeishMan’ topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani

Por Ganguly, Agneyo, Das, Benu Brata, Sen, Nilkantha, Roy, Amit, Dasgupta, Somdeb Bose, Majumder, Hemanta K.
Publicado em 2006

Flavone-resistant Leishmania donovani Overexpresses LdMRP2 Transporter in the Parasite and Activates Host MRP2 on Macrophages to Circumvent the Flavone-mediated Cell Death

Por Chowdhury, Sayan, Mukhopadhyay, Rupkatha, Saha, Sourav, Mishra, Amartya, Sengupta, Souvik, Roy, Syamal, Majumder, Hemanta K.
Publicado em 2014

Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response

Por Mishra, Amartya, Vinayagam, Jayaraman, Saha, Sourav, Chowdhury, Sayan, Roychowdhury, Somenath, Jaisankar, Parasuraman, Majumder, Hemanta K
Publicado em 2014

Disuccinyl Betulin Triggers Metacaspase-Dependent Endonuclease G-Mediated Cell Death in Unicellular Protozoan Parasite Leishmania donovani

Por Chowdhury, Sayan, Mukherjee, Tulika, Chowdhury, Somenath Roy, Sengupta, Souvik, Mukhopadhyay, Sibabrata, Jaisankar, Parasuraman, Majumder, Hemanta K.
Publicado em 2014

ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism

Por Sengupta, Souvik, Ganguly, Agneyo, Roy, Amit, BoseDasgupta, Somdeb, D’Annessa, Ilda, Desideri, Alessandro, Majumder, Hemanta K.
Publicado em 2011

Development of Derivatives of 3, 3′-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons

Por Roy, Amit, Chowdhury, Sayan, Sengupta, Souvik, Mandal, Madhumita, Jaisankar, Parasuraman, D'Annessa, Ilda, Desideri, Alessandro, Majumder, Hemanta K.
Publicado em 2011

The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice

Por Chowdhury, Sayan, Mukherjee, Tulika, Mukhopadhyay, Rupkatha, Mukherjee, Budhaditya, Sengupta, Souvik, Chattopadhyay, Sharmila, Jaisankar, Parasuraman, Roy, Syamal, Majumder, Hemanta K
Publicado em 2012

A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase

Por Saha, Sourav, Acharya, Chiranjit, Pal, Uttam, Chowdhury, Somenath Roy, Sarkar, Kahini, Maiti, Nakul C., Jaisankar, Parasuraman, Majumder, Hemanta K.
Publicado no Antimicrob Agents Chemother (2016)

Differential induction of Leishmania donovani bi-subunit topoisomerase I–DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resis...

Por Das, Benu Brata, Sen, Nilkantha, Roy, Amit, Dasgupta, Somdeb Bose, Ganguly, Agneyo, Mohanta, Bikash Chandra, Dinda, Biswanath, Majumder, Hemanta K.
Publicado em 2006