‘LeishMan’ topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani

The active site tyrosine residue of all monomeric type IB topoisomerases resides in the C-terminal domain of the enzyme. Leishmania donovani, possesses unusual heterodimeric type IB topoisomerase. The small subunit harbors the catalytic tyrosine within the SKXXY motif. To explore the functional rela...

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Detalhes bibliográficos
Main Authors: Ganguly, Agneyo, Das, Benu Brata, Sen, Nilkantha, Roy, Amit, Dasgupta, Somdeb Bose, Majumder, Hemanta K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1669778/
https://ncbi.nlm.nih.gov/pubmed/17098934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl829
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