載入...

Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani towards 3,3′-Diindolylmethane

3,3′-Diindolylmethane (DIM), a novel poison targeting Leishmania donovani topoisomerase I (LdTOP1LS), induces programmed cell death in Leishmania parasites. The development of resistant parasites by adaptation with increasing concentrations of DIM generates random mutations in LdTOP1LS. Single-nucle...

全面介紹

Na minha lista:

書目詳細資料
Main Authors:	Roy, Amit, BoseDasgupta, Somdeb, Ganguly, Agneyo, Jaisankar, Parasuraman, Majumder, Hemanta K.
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 2009
主題:	Mechanisms of Resistance
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2687245/ https://ncbi.nlm.nih.gov/pubmed/19332675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01648-08
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani towards 3,3′-Diindolylmethane

相似書籍