Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani towards 3,3′-Diindolylmethane

3,3′-Diindolylmethane (DIM), a novel poison targeting Leishmania donovani topoisomerase I (LdTOP1LS), induces programmed cell death in Leishmania parasites. The development of resistant parasites by adaptation with increasing concentrations of DIM generates random mutations in LdTOP1LS. Single-nucle...

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Autors principals: Roy, Amit, BoseDasgupta, Somdeb, Ganguly, Agneyo, Jaisankar, Parasuraman, Majumder, Hemanta K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687245/
https://ncbi.nlm.nih.gov/pubmed/19332675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01648-08
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