Development of Derivatives of 3, 3′-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons

BACKGROUND: The development of 3, 3′-diindolyl methane (DIM) resistant parasite Leishmania donovani (LdDR50) by adaptation with increasing concentrations of the drug generates random mutations in the large and small subunits of heterodimeric DNA topoisomerase I of Leishmania (LdTOP1LS). Mutation of...

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Bibliographic Details
Main Authors: Roy, Amit, Chowdhury, Sayan, Sengupta, Souvik, Mandal, Madhumita, Jaisankar, Parasuraman, D'Annessa, Ilda, Desideri, Alessandro, Majumder, Hemanta K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3236199/
https://ncbi.nlm.nih.gov/pubmed/22174820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028493
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