The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice

Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti-leishmanial agent. The compound induces topoisomerase I-mediated DNA–prot...

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Autors principals: Chowdhury, Sayan, Mukherjee, Tulika, Mukhopadhyay, Rupkatha, Mukherjee, Budhaditya, Sengupta, Souvik, Chattopadhyay, Sharmila, Jaisankar, Parasuraman, Roy, Syamal, Majumder, Hemanta K
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491841/
https://ncbi.nlm.nih.gov/pubmed/23027614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201316
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