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The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice
Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. In the present study, we have shown for the first time that niranthin is a potent anti-leishmanial agent. The compound induces topoisomerase I-mediated DNA–prot...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
WILEY-VCH Verlag
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491841/ https://ncbi.nlm.nih.gov/pubmed/23027614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201316 |
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