Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

od Luth, Madeline R., Gupta, Purva, Ottilie, Sabine, Winzeler, Elizabeth A.
Izdano u ACS Infect Dis (2018)

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

od Rosenberg, Alex, Luth, Madeline R., Winzeler, Elizabeth A., Behnke, Michael, Sibley, L. David
Izdano u Proc Natl Acad Sci U S A (2019)

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

od Debnath, Anjan, Calvet, Claudia M., Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R., Abagyan, Ruben, Nes, W. David, McKerrow, James H., Podust, Larissa M.
Izdano u PLoS Negl Trop Dis (2017)

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

od Stokes, Barbara H., Yoo, Euna, Murithi, James M., Luth, Madeline R., Afanasyev, Pavel, da Fonseca, Paula C. A., Winzeler, Elizabeth A., Ng, Caroline L., Bogyo, Matthew, Fidock, David A.
Izdano u PLoS Pathog (2019)

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

od Mandt, Rebecca E. K., Lafuente-Monasterio, Maria Jose, Sakata-Kato, Tomoyo, Luth, Madeline R., Segura, Delfina, Pablos-Tanarro, Alba, Viera, Sara, Magan, Noemi, Ottilie, Sabine, Winzeler, Elizabeth A., Lukens, Amanda K., Gamo, Francisco Javier, Wirth, Dyann F.
Izdano u Sci Transl Med (2019)

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum

od Rocamora, Frances, Gupta, Purva, Istvan, Eva S., Luth, Madeline R., Carpenter, Emma F., Kümpornsin, Krittikorn, Sasaki, Erika, Calla, Jaeson, Mittal, Nimisha, Carolino, Krypton, Owen, Edward, Llinás, Manuel, Ottilie, Sabine, Goldberg, Daniel E., Lee, Marcus C. S., Winzeler, Elizabeth A.
Izdano u ACS Infect Dis (2021)

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

od Abraham, Matthew, Gagaring, Kerstin, Martino, Marisa L., Vanaerschot, Manu, Plouffe, David M., Calla, Jaeson, Godinez-Macias, Karla P., Du, Alan Y., Wree, Melanie, Antonova-Koch, Yevgeniya, Eribez, Korina, Luth, Madeline R., Ottilie, Sabine, Fidock, David A., McNamara, Case W., Winzeler, Elizabeth A.
Izdano u ACS Infect Dis (2020)

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

od Xie, Stanley C., Gillett, David L., Spillman, Natalie J., Tsu, Christopher, Luth, Madeline R., Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E., Hales, Paul, Seager, Benjamin A., Charron, Carlie L., Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A., Burrows, Jeremy N., Winzeler, Elizabeth A., Avery, Vicky M., Dick, Lawrence R., Tilley, Leann
Izdano u J Med Chem (2018)

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

od LaMonte, Gregory M., Rocamora, Frances, Marapana, Danushka S., Gnädig, Nina F., Ottilie, Sabine, Luth, Madeline R., Worgall, Tilla S., Goldgof, Gregory M., Mohunlal, Roxanne, Santha Kumar, T. R., Thompson, Jennifer K., Vigil, Edgar, Yang, Jennifer, Hutson, Dylan, Johnson, Trevor, Huang, Jianbo, Williams, Roy M., Zou, Bing Yu, Cheung, Andrea L., Kumar, Prianka, Egan, Timothy J., Lee, Marcus C. S., Siegel, Dionicio, Cowman, Alan F., Fidock, David A., Winzeler, Elizabeth A.
Izdano u Nat Commun (2020)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

od Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo, Vanaerschot, Manu, Owen, Edward, Jado, Juan Carlos, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McLean, Cheung, Andrea L., Lincoln, Christie, Ambachew, Biniam, Rouillier, Melanie, Siegel, Dionicio, Nosten, François, Kyle, Dennis E., Gamo, Francisco-Javier, Zhou, Yingyao, Llinás, Manuel, Fidock, David A., Wirth, Dyann F., Burrows, Jeremy, Campo, Brice, Winzeler, Elizabeth A.
Izdano u Science (2018)

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

od Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann
Izdano u Science (2022)