Novel Antimalarial Tetrazoles and Amides Active Against the Hemoglobin Degradation Pathway in Plasmodium falciparum

af Lawong, Aloysus, Gahalawat, Suraksha, Okombo, John, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Deni, Ioanna, Bridgford, Jessica L., Niederstrasser, Hanspeter, Zhou, Anwu, Posner, Bruce, Wittlin, Sergio, Gamo, Francisco Javier, Crespo, Benigno, Churchyard, Alisje, Baum, Jake, Mittal, Nimisha, Winzeler, Elizabeth, Laleu, Benoît, Palmer, Michael J., Charman, Susan A., Fidock, David A., Ready, Joseph M., Phillips, Margaret A.
Udgivet i J Med Chem (2021)

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

af Okaniwa, Masanori, Shibata, Akira, Ochida, Atsuko, Akao, Yuichiro, White, Karen L., Shackleford, David M., Duffy, Sandra, Lucantoni, Leonardo, Dey, Sumanta, Striepen, Josefine, Yeo, Tomas, Mok, Sachel, Aguiar, Anna Caroline C., Sturm, Angelika, Crespo, Benigno, Sanz, Laura M., Churchyard, Alisje, Baum, Jake, Pereira, Dhelio B., Guido, Rafael V. C., Dechering, Koen J., Wittlin, Sergio, Uhlemann, Anne-Catrin, Fidock, David A., Niles, Jacquin C., Avery, Vicky M., Charman, Susan A., Laleu, Benoît
Udgivet i ACS Infect Dis (2021)

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

af Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann
Udgivet i Science (2022)