Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

Por Luth, Madeline R., Gupta, Purva, Ottilie, Sabine, Winzeler, Elizabeth A.
Publicado no ACS Infect Dis (2018)

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

Por Rosenberg, Alex, Luth, Madeline R., Winzeler, Elizabeth A., Behnke, Michael, Sibley, L. David
Publicado no Proc Natl Acad Sci U S A (2019)

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

Por Debnath, Anjan, Calvet, Claudia M., Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R., Abagyan, Ruben, Nes, W. David, McKerrow, James H., Podust, Larissa M.
Publicado no PLoS Negl Trop Dis (2017)

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

Por Stokes, Barbara H., Yoo, Euna, Murithi, James M., Luth, Madeline R., Afanasyev, Pavel, da Fonseca, Paula C. A., Winzeler, Elizabeth A., Ng, Caroline L., Bogyo, Matthew, Fidock, David A.
Publicado no PLoS Pathog (2019)

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

Por Mandt, Rebecca E. K., Lafuente-Monasterio, Maria Jose, Sakata-Kato, Tomoyo, Luth, Madeline R., Segura, Delfina, Pablos-Tanarro, Alba, Viera, Sara, Magan, Noemi, Ottilie, Sabine, Winzeler, Elizabeth A., Lukens, Amanda K., Gamo, Francisco Javier, Wirth, Dyann F.
Publicado no Sci Transl Med (2019)

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

Por Abraham, Matthew, Gagaring, Kerstin, Martino, Marisa L., Vanaerschot, Manu, Plouffe, David M., Calla, Jaeson, Godinez-Macias, Karla P., Du, Alan Y., Wree, Melanie, Antonova-Koch, Yevgeniya, Eribez, Korina, Luth, Madeline R., Ottilie, Sabine, Fidock, David A., McNamara, Case W., Winzeler, Elizabeth A.
Publicado no ACS Infect Dis (2020)

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

Por Xie, Stanley C., Gillett, David L., Spillman, Natalie J., Tsu, Christopher, Luth, Madeline R., Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E., Hales, Paul, Seager, Benjamin A., Charron, Carlie L., Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A., Burrows, Jeremy N., Winzeler, Elizabeth A., Avery, Vicky M., Dick, Lawrence R., Tilley, Leann
Publicado no J Med Chem (2018)

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Por LaMonte, Gregory M., Rocamora, Frances, Marapana, Danushka S., Gnädig, Nina F., Ottilie, Sabine, Luth, Madeline R., Worgall, Tilla S., Goldgof, Gregory M., Mohunlal, Roxanne, Santha Kumar, T. R., Thompson, Jennifer K., Vigil, Edgar, Yang, Jennifer, Hutson, Dylan, Johnson, Trevor, Huang, Jianbo, Williams, Roy M., Zou, Bing Yu, Cheung, Andrea L., Kumar, Prianka, Egan, Timothy J., Lee, Marcus C. S., Siegel, Dionicio, Cowman, Alan F., Fidock, David A., Winzeler, Elizabeth A.
Publicado no Nat Commun (2020)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

Por Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo, Vanaerschot, Manu, Owen, Edward, Jado, Juan Carlos, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McLean, Cheung, Andrea L., Lincoln, Christie, Ambachew, Biniam, Rouillier, Melanie, Siegel, Dionicio, Nosten, François, Kyle, Dennis E., Gamo, Francisco-Javier, Zhou, Yingyao, Llinás, Manuel, Fidock, David A., Wirth, Dyann F., Burrows, Jeremy, Campo, Brice, Winzeler, Elizabeth A.
Publicado no Science (2018)

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

Por Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann
Publicado no Science (2022)