In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in clinical use, prompting the need to characterize the pathways mediating resistance. Here, we report a framework for assessing development of resistance of Plasmodium falciparum to new antimalarial therapeutics. We...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Mandt, Rebecca E. K., Lafuente-Monasterio, Maria Jose, Sakata-Kato, Tomoyo, Luth, Madeline R., Segura, Delfina, Pablos-Tanarro, Alba, Viera, Sara, Magan, Noemi, Ottilie, Sabine, Winzeler, Elizabeth A., Lukens, Amanda K., Gamo, Francisco Javier, Wirth, Dyann F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7444640/
https://ncbi.nlm.nih.gov/pubmed/31801884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav1636
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