Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

ανά Luth, Madeline R., Gupta, Purva, Ottilie, Sabine, Winzeler, Elizabeth A.
Τόπος έκδοσης ACS Infect Dis (2018)

Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii

ανά Rosenberg, Alex, Luth, Madeline R., Winzeler, Elizabeth A., Behnke, Michael, Sibley, L. David
Τόπος έκδοσης Proc Natl Acad Sci U S A (2019)

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM)

ανά Debnath, Anjan, Calvet, Claudia M., Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R., Abagyan, Ruben, Nes, W. David, McKerrow, James H., Podust, Larissa M.
Τόπος έκδοσης PLoS Negl Trop Dis (2017)

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

ανά Stokes, Barbara H., Yoo, Euna, Murithi, James M., Luth, Madeline R., Afanasyev, Pavel, da Fonseca, Paula C. A., Winzeler, Elizabeth A., Ng, Caroline L., Bogyo, Matthew, Fidock, David A.
Τόπος έκδοσης PLoS Pathog (2019)

In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model

ανά Mandt, Rebecca E. K., Lafuente-Monasterio, Maria Jose, Sakata-Kato, Tomoyo, Luth, Madeline R., Segura, Delfina, Pablos-Tanarro, Alba, Viera, Sara, Magan, Noemi, Ottilie, Sabine, Winzeler, Elizabeth A., Lukens, Amanda K., Gamo, Francisco Javier, Wirth, Dyann F.
Τόπος έκδοσης Sci Transl Med (2019)

PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum

ανά Rocamora, Frances, Gupta, Purva, Istvan, Eva S., Luth, Madeline R., Carpenter, Emma F., Kümpornsin, Krittikorn, Sasaki, Erika, Calla, Jaeson, Mittal, Nimisha, Carolino, Krypton, Owen, Edward, Llinás, Manuel, Ottilie, Sabine, Goldberg, Daniel E., Lee, Marcus C. S., Winzeler, Elizabeth A.
Τόπος έκδοσης ACS Infect Dis (2021)

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

ανά Abraham, Matthew, Gagaring, Kerstin, Martino, Marisa L., Vanaerschot, Manu, Plouffe, David M., Calla, Jaeson, Godinez-Macias, Karla P., Du, Alan Y., Wree, Melanie, Antonova-Koch, Yevgeniya, Eribez, Korina, Luth, Madeline R., Ottilie, Sabine, Fidock, David A., McNamara, Case W., Winzeler, Elizabeth A.
Τόπος έκδοσης ACS Infect Dis (2020)

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

ανά Xie, Stanley C., Gillett, David L., Spillman, Natalie J., Tsu, Christopher, Luth, Madeline R., Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E., Hales, Paul, Seager, Benjamin A., Charron, Carlie L., Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A., Burrows, Jeremy N., Winzeler, Elizabeth A., Avery, Vicky M., Dick, Lawrence R., Tilley, Leann
Τόπος έκδοσης J Med Chem (2018)

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

ανά LaMonte, Gregory M., Rocamora, Frances, Marapana, Danushka S., Gnädig, Nina F., Ottilie, Sabine, Luth, Madeline R., Worgall, Tilla S., Goldgof, Gregory M., Mohunlal, Roxanne, Santha Kumar, T. R., Thompson, Jennifer K., Vigil, Edgar, Yang, Jennifer, Hutson, Dylan, Johnson, Trevor, Huang, Jianbo, Williams, Roy M., Zou, Bing Yu, Cheung, Andrea L., Kumar, Prianka, Egan, Timothy J., Lee, Marcus C. S., Siegel, Dionicio, Cowman, Alan F., Fidock, David A., Winzeler, Elizabeth A.
Τόπος έκδοσης Nat Commun (2020)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

ανά Antonova-Koch, Yevgeniya, Meister, Stephan, Abraham, Matthew, Luth, Madeline R., Ottilie, Sabine, Lukens, Amanda K., Sakata-Kato, Tomoyo, Vanaerschot, Manu, Owen, Edward, Jado, Juan Carlos, Maher, Steven P., Calla, Jaeson, Plouffe, David, Zhong, Yang, Chen, Kaisheng, Chaumeau, Victor, Conway, Amy J., McNamara, Case W., Ibanez, Maureen, Gagaring, Kerstin, Serrano, Fernando Neria, Eribez, Korina, Taggard, Cullin McLean, Cheung, Andrea L., Lincoln, Christie, Ambachew, Biniam, Rouillier, Melanie, Siegel, Dionicio, Nosten, François, Kyle, Dennis E., Gamo, Francisco-Javier, Zhou, Yingyao, Llinás, Manuel, Fidock, David A., Wirth, Dyann F., Burrows, Jeremy, Campo, Brice, Winzeler, Elizabeth A.
Τόπος έκδοσης Science (2018)

Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy

ανά Xie, Stanley C., Metcalfe, Riley D., Dunn, Elyse, Morton, Craig J., Huang, Shih-Chung, Puhalovich, Tanya, Du, Yawei, Wittlin, Sergio, Nie, Shuai, Luth, Madeline R., Ma, Liting, Kim, Mi-Sook, Pasaje, Charisse Flerida A., Kumpornsin, Krittikorn, Giannangelo, Carlo, Houghton, Fiona J., Churchyard, Alisje, Famodimu, Mufuliat T., Barry, Daniel C., Gillett, David L., Dey, Sumanta, Kosasih, Clara C., Newman, William, Niles, Jacquin C., Lee, Marcus C.S., Baum, Jake, Ottilie, Sabine, Winzeler, Elizabeth A., Creek, Darren J., Williamson, Nicholas, Parker, Michael W., Brand, Stephen L., Langston, Steven P., Dick, Lawrence R., Griffin, Michael D.W., Gould, Alexandra E., Tilley, Leann
Τόπος έκδοσης Science (2022)