5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation

Por Choi, Inchan, Kim, Rinho, Lim, Hee-Woong, Kaestner, Klaus H, Won, Kyoung-Jae
Publicado em 2014

Nuclear Receptor Corepressors are Required for the Histone Deacetylase Activity of HDAC3 In Vivo

Por You, Seo-Hee, Lim, Hee-Woong, Sun, Zheng, Broache, Molly, Won, Kyoung-Jae, Lazar, Mitchell A.
Publicado em 2013

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

Por Wang, Wenshan, Kissig, Megan, Rajakumari, Sona, Huang, Li, Lim, Hee-woong, Won, Kyoung-Jae, Seale, Patrick
Publicado em 2014

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

Por Stine, Rachel R., Shapira, Suzanne N., Lim, Hee-Woong, Ishibashi, Jeff, Harms, Matthew, Won, Kyoung-Jae, Seale, Patrick
Publicado no Mol Metab (2015)

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice

Por Harms, Matthew J., Ishibashi, Jeff, Wang, Wenshan, Lim, Hee-Woong, Goyama, Susumu, Sato, Tomohiko, Kurokawa, Mineo, Won, Kyoung-Jae, Seale, Patrick
Publicado em 2014

Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers

Por Step, Sonia E., Lim, Hee-Woong, Marinis, Jill M., Prokesch, Andreas, Steger, David J., You, Seo-Hee, Won, Kyoung-Jae, Lazar, Mitchell A.
Publicado em 2014

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

Por Lim, Hee-Woong, Uhlenhaut, N. Henriette, Rauch, Alexander, Weiner, Juliane, Hübner, Sabine, Hübner, Norbert, Won, Kyoung-Jae, Lazar, Mitchell A., Tuckermann, Jan, Steger, David J.
Publicado no Genome Res (2015)

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program

Por Harms, Matthew J., Lim, Hee-Woong, Ho, Yugong, Shapira, Suzanne N., Ishibashi, Jeff, Rajakumari, Sona, Steger, David J., Lazar, Mitchell A., Won, Kyoung-Jae, Seale, Patrick
Publicado no Genes Dev (2015)

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling

Por Jager, Jennifer, Wang, Fenfen, Fang, Bin, Lim, Hee-Woong, Peed, Lindsey C., Steger, David J., Won, Kyoung-Jae, Kharitonenkov, Alexei, Adams, Andrew C., Lazar, Mitchell A.
Publicado no J Biol Chem (2016)

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

Por Sun, Zheng, Feng, Dan, Fang, Bin, Mullican, Shannon E., You, Seo-Hee, Lim, Hee-Woong, Everett, Logan J., Nabel, Christopher S., Li, Yun, Selvakumaran, Vignesh, Won, Kyoung-Jae, Lazar, Mitchell A.
Publicado em 2013

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

Por Shah, Supriya, Carriveau, Whitney J., Li, Jinyang, Campbell, Sydney L., Kopinski, Piotr K., Lim, Hee-Woong, Daurio, Natalie, Trefely, Sophie, Won, Kyoung-Jae, Wallace, Douglas C., Koumenis, Constantinos, Mancuso, Anthony, Wellen, Kathryn E.
Publicado no Oncotarget (2016)

Dynamic chromatin remodeling mediated by Polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells

Por Xie, Ruiyu, Everett, Logan J., Lim, Hee-Woong, Patel, Nisha A., Schug, Jonathan, Kroon, Evert, Kelly, Olivia G, Wang, Allen, D’Amour, Kevin A., Robins, Allan J., Won, Kyoung-Jae, Kaestner, Klaus H., Sander, Maike
Publicado em 2013

Genetic Variation Determines PPARγ Function and Antidiabetic Drug Response In Vivo

Por Soccio, Raymond E., Chen, Eric R., Rajapurkar, Satyajit R., Safabakhsh, Pegah, Marinis, Jill M., Dispirito, Joanna R., Emmett, Matthew J., Briggs, Erika R., Fang, Bin, Everett, Logan J., Lim, Hee-Woong, Won, Kyoung-Jae, Steger, David J., Wu, Ying, Civelek, Mete, Voight, Benjamin F., Lazar, Mitchell A.
Publicado no Cell (2015)

LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells

Por Ediger, Benjamin N., Lim, Hee-Woong, Juliana, Christine, Groff, David N., Williams, LaQueena T., Dominguez, Giselle, Liu, Jin-Hua, Taylor, Brandon L., Walp, Erik R., Kameswaran, Vasumathi, Yang, Juxiang, Liu, Chengyang, Hunter, Chad S., Kaestner, Klaus H., Naji, Ali, Li, Changhong, Sander, Maike, Stein, Roland, Sussel, Lori, Won, Kyoung-Jae, May, Catherine Lee, Stoffers, Doris A.
Publicado no J Clin Invest (2016)

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Por Lee, Joyce V., Carrer, Alessandro, Shah, Supriya, Snyder, Nathaniel W., Wei, Shuanzeng, Venneti, Sriram, Worth, Andrew J., Yuan, Zuo-Fei, Lim, Hee-Woong, Liu, Shichong, Jackson, Ellen, Aiello, Nicole M., Haas, Naomi B., Rebbeck, Timothy R., Judkins, Alexander, Won, Kyoung-Jae, Chodosh, Lewis A., Garcia, Benjamin A., Stanger, Ben Z., Feldman, Michael D., Blair, Ian A., Wellen, Kathryn E.
Publicado em 2014

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice

Por Soccio, Raymond E., Li, Zhenghui, Chen, Eric R., Foong, Yee Hoon, Benson, Kiara K., Dispirito, Joanna R., Mullican, Shannon E., Emmett, Matthew J., Briggs, Erika R., Peed, Lindsey C., Dzeng, Richard K., Medina, Carlos J., Jolivert, Jennifer F., Kissig, Megan, Rajapurkar, Satyajit R., Damle, Manashree, Lim, Hee-Woong, Won, Kyoung-Jae, Seale, Patrick, Steger, David J., Lazar, Mitchell A.
Publicado no J Clin Invest (2017)