Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Histone acetylation plays important roles in gene regulation, DNA replication, and the response to DNA damage, and it is frequently deregulated in tumors. We postulated that tumor cell histone acetylation levels are determined in part by changes in acetyl-CoA availability mediated by oncogenic metab...

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Detalhes bibliográficos
Main Authors: Lee, Joyce V., Carrer, Alessandro, Shah, Supriya, Snyder, Nathaniel W., Wei, Shuanzeng, Venneti, Sriram, Worth, Andrew J., Yuan, Zuo-Fei, Lim, Hee-Woong, Liu, Shichong, Jackson, Ellen, Aiello, Nicole M., Haas, Naomi B., Rebbeck, Timothy R., Judkins, Alexander, Won, Kyoung-Jae, Chodosh, Lewis A., Garcia, Benjamin A., Stanger, Ben Z., Feldman, Michael D., Blair, Ian A., Wellen, Kathryn E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151270/
https://ncbi.nlm.nih.gov/pubmed/24998913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.06.004
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