Inhibition of Neuronal Cell Mitochondrial Complex I with Rotenone Increases Lipid β-Oxidation, Supporting Acetyl-Coenzyme A Levels

Rotenone is a naturally occurring mitochondrial complex I inhibitor with a known association with parkinsonian phenotypes in both human populations and rodent models. Despite these findings, a clear mechanistic link between rotenone exposure and neuronal damage remains to be determined. Here, we rep...

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Autors principals: Worth, Andrew J., Basu, Sankha S., Snyder, Nathaniel W., Mesaros, Clementina, Blair, Ian A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Lipids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175330/
https://ncbi.nlm.nih.gov/pubmed/25122772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591354
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