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Rotenone-Mediated Changes in Intracellular Coenzyme A Thioester Levels: Implications for Mitochondrial Dysfunction

[Image: see text] Rotenone, an organic pesticide and potent mitochondrial complex I inhibitor, causes Parkinson-like neurodegeneration in rodents and is implicated in human Parkinson’s disease. In this rapid report, rotenone induced a dose-dependent decrease in succinyl-coenzyme A (CoA) and increase...

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Hlavní autoři: Basu, Sankha S., Blair, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2011
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196242/
https://ncbi.nlm.nih.gov/pubmed/21950265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200366j
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