Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells

The α-ketoglutarate metabolite, 2-hydroxyglutarate (2-HG), has emerged as an important mediator in a subset of cancers and rare inherited inborn errors of metabolism. Because of potential enantiospecific metabolism, chiral analysis is essential for determining the biochemical impacts of altered 2-HG...

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Udgivet i:Chem Res Toxicol
Main Authors: Worth, Andrew J., Gillespie, Kevin P., Mesaros, Clementina, Guo, Lili, Basu, Sankha S., Snyder, Nathaniel W., Blair, Ian A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721232/
https://ncbi.nlm.nih.gov/pubmed/25800467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500535c
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