Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severe hepatosteatosis. Here we show that pharmacologic HDAC inhibition in primary hepatocytes causes histone hype...

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Detalhes bibliográficos
Main Authors: Sun, Zheng, Feng, Dan, Fang, Bin, Mullican, Shannon E., You, Seo-Hee, Lim, Hee-Woong, Everett, Logan J., Nabel, Christopher S., Li, Yun, Selvakumaran, Vignesh, Won, Kyoung-Jae, Lazar, Mitchell A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877208/
https://ncbi.nlm.nih.gov/pubmed/24268577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.022
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