Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

Histone deacetylases (HDACs) are believed to regulate gene transcription by catalyzing deacetylation reactions. HDAC3 depletion in mouse liver upregulates lipogenic genes and results in severe hepatosteatosis. Here we show that pharmacologic HDAC inhibition in primary hepatocytes causes histone hype...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Sun, Zheng, Feng, Dan, Fang, Bin, Mullican, Shannon E., You, Seo-Hee, Lim, Hee-Woong, Everett, Logan J., Nabel, Christopher S., Li, Yun, Selvakumaran, Vignesh, Won, Kyoung-Jae, Lazar, Mitchell A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877208/
https://ncbi.nlm.nih.gov/pubmed/24268577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.022
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge