The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes

Por Lang, Veronica, Light, Peter E
Publicado em 2010

Pharmacological activation of plasma-membrane K(ATP) channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential

Por Baczkó, István, Giles, Wayne R, Light, Peter E
Publicado em 2004

Resting Membrane Potential Regulates Na(+)–Ca(2+) Exchange-Mediated Ca(2+) Overload during Hypoxia–Reoxygenation in Rat Ventricular Myocytes

Por Baczkó, István, Giles, Wayne R, Light, Peter E
Publicado em 2003

Cardioselectivity of the sulphonylurea HMR 1098: studies on native and recombinant cardiac and pancreatic K(ATP) channels

Por Manning Fox, Jocelyn E, Kanji, Hussein D, French, Robert J, Light, Peter E
Publicado em 2002

The ATP-Sensitive K(+) Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

Por Fatehi, Mohammad, Raja, Mobeen, Carter, Christian, Soliman, Daniel, Holt, Andrew, Light, Peter E.
Publicado em 2012

Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels

Por Light, Peter E., Bladen, Christopher, Winkfein, Robert J., Walsh, Michael P., French, Robert J.
Publicado em 2000

Intracellular Long-Chain Acyl CoAs Activate TRPV1 Channels

Por Yu, Yi, Carter, Chris R. J., Youssef, Nermeen, Dyck, Jason R. B., Light, Peter E.
Publicado em 2014

Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B

Por Thorneloe, Kevin S, Maruyama, Yoshiaki, Malcolm, A Todd, Light, Peter E, Walsh, Michael P, Cole, William C
Publicado em 2002

Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity

Por Fatehi, Mohammad, Carter, Chris R.J., Youssef, Nermeen, Hunter, Beth E., Holt, Andrew, Light, Peter E.
Publicado no Biosci Rep (2015)

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K(+) Channel

Por Hamming, Kevin S.C., Soliman, Daniel, Matemisz, Laura C., Niazi, Omid, Lang, Yiqiao, Gloyn, Anna L., Light, Peter E.
Publicado em 2009

Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy

Por Alvarez, Bernardo V, Johnson, Danielle E, Sowah, Daniel, Soliman, Daniel, Light, Peter E, Xia, Ying, Karmazyn, Morris, Casey, Joseph R
Publicado em 2007

Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction

Por Polewicz, Dorota, Cadete, Virgilio J J, Doroszko, Adrian, Hunter, Beth E, Sawicka, Jolanta, Szczesna-Cordary, Danuta, Light, Peter E, Sawicki, Grzegorz
Publicado em 2011

The Third Intracellular Loop Stabilizes the Inactive State of the Neuropeptide Y1 Receptor

Por Chee, Melissa J. S., Mörl, Karin, Lindner, Diana, Merten, Nicole, Zamponi, Gerald W., Light, Peter E., Beck-Sickinger, Annette G., Colmers, William F.
Publicado em 2008

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

Por Chan, Anita Y. M., Dolinsky, Vernon W., Soltys, Carrie-Lynn M., Viollet, Benoit, Baksh, Shairaz, Light, Peter E., Dyck, Jason R. B.
Publicado em 2008

Hypothalamic glucagon signals through the K(ATP) channels to regulate glucose production()

Por Abraham, Mona A., Yue, Jessica T.Y., LaPierre, Mary P., Rutter, Guy A., Light, Peter E., Filippi, Beatrice M., Lam, Tony K.T.
Publicado em 2013

Splice Variant-Dependent Regulation of β-Cell Sodium-Calcium Exchange by Acyl-Coenzyme As

Por Hamming, Kevin S. C., Riedel, Michael J., Soliman, Daniel, Matemisz, Laura C., Webster, Nicola J., Searle, Gavin J., MacDonald, Patrick E., Light, Peter E.
Publicado no Mol Endocrinol (2008)

Metabolic regulation of sodium–calcium exchange by intracellular acyl CoAs

Por Riedel, Michael J, Baczkó, István, Searle, Gavin J, Webster, Nicola, Fercho, Matthew, Jones, Lynn, Lang, Jessica, Lytton, Jonathan, Dyck, Jason R B, Light, Peter E
Publicado em 2006

Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction

Por Kienesberger, Petra C., Pulinilkunnil, Thomas, Sung, Miranda M. Y., Nagendran, Jeevan, Haemmerle, Guenter, Kershaw, Erin E., Young, Martin E., Light, Peter E., Oudit, Gavin Y., Zechner, Rudolf, Dyck, Jason R. B.
Publicado em 2012

Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis

Por Ondrusova, Katarina, Fatehi, Mohammad, Barr, Amy, Czarnecka, Zofia, Long, Wentong, Suzuki, Kunimasa, Campbell, Scott, Philippaert, Koenraad, Hubert, Matthew, Tredget, Edward, Kwan, Peter, Touret, Nicolas, Wabitsch, Martin, Lee, Kevin Y., Light, Peter E.
Publicado no Sci Rep (2017)

Calreticulin Induces Dilated Cardiomyopathy

Por Lee, Dukgyu, Oka, Tatsujiro, Hunter, Beth, Robinson, Alison, Papp, Sylvia, Nakamura, Kimitoshi, Srisakuldee, Wattamon, Nickel, Barbara E., Light, Peter E., Dyck, Jason R. B., Lopaschuk, Gary D., Kardami, Elissavet, Opas, Michal, Michalak, Marek
Publicado em 2013