Hypothalamic glucagon signals through the K(ATP) channels to regulate glucose production()

Insulin, leptin and GLP-1 signal in the mediobasal hypothalamus (MBH) to lower hepatic glucose production (GP). MBH glucagon action also inhibits GP but the downstream signaling mediators remain largely unknown. In parallel, a lipid-sensing pathway involving MBH AMPK→malonyl-CoA→CPT-1→LCFA-CoA→PKC-δ...

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Detalhes bibliográficos
Main Authors: Abraham, Mona A., Yue, Jessica T.Y., LaPierre, Mary P., Rutter, Guy A., Light, Peter E., Filippi, Beatrice M., Lam, Tony K.T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953686/
https://ncbi.nlm.nih.gov/pubmed/24634823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2013.11.007
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