Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction

Damage to cardiac contractile proteins during ischemia followed by reperfusion is mediated by reactive oxygen species such as peroxynitrite (ONOO(−)), resulting in impairment of cardiac systolic function. However, the pathophysiology of systolic dysfunction during ischemia only, before reperfusion,...

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Detalhes bibliográficos
Main Authors: Polewicz, Dorota, Cadete, Virgilio J J, Doroszko, Adrian, Hunter, Beth E, Sawicka, Jolanta, Szczesna-Cordary, Danuta, Light, Peter E, Sawicki, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953580/
https://ncbi.nlm.nih.gov/pubmed/20518849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2010.01094.x
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