Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury

BACKGROUND: Although mechanical ventilation (MV) is a major supportive therapy for patients with acute respiratory distress syndrome, it may result in side effects including lung injury. In this study we hypothesize that MMP-9 inhibition by doxycycline might reduce MV-related lung damage. Using a pr...

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Main Authors: Doroszko, Adrian, Hurst, Thomas S, Polewicz, Dorota, Sawicka, Jolanta, Fert-Bober, Justyna, Johnson, David H, Sawicki, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824689/
https://ncbi.nlm.nih.gov/pubmed/20205825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-8-3
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