Vancomycin resistance: Modeling backbone variants with d-Ala-d-Ala and d-Ala-d-Lac peptides

Por Leung, Siegfried S. F., Tirado-Rives, Julian, Jorgensen, William L.
Publicado em 2008

Vancomycin analogs: Seeking improved binding of D-Ala-D-Ala and D-Ala-D-Lac peptides by side-chain and backbone modifications

Por Leung, Siegfried S. F., Tirado-Rives, Julian, Jorgensen, William L.
Publicado em 2009

Testing Physical Models of Passive Membrane Permeation

Por Leung, Siegfried S. F., Mijalkovic, Jona, Borrelli, Kenneth, Jacobson, Matthew P.
Publicado em 2012

Methyl Effects on Protein–Ligand Binding

Por Leung, Cheryl S., Leung, Siegfried S. F., Tirado-Rives, Julian, Jorgensen, William L.
Publicado em 2012

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

Por Chen, Chiung-Kuang, Leung, Siegfried S. F., Guilbert, Christophe, Jacobson, Matthew P., McKerrow, James H., Podust, Larissa M.
Publicado em 2010

Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon

Por Crane, Christine M., Pierce, Joshua G., Leung, Siegfried S. F., Tirado-Rives, Julian, Jorgensen, William L., Boger, Dale L.
Publicado em 2010

A Nonazole CYP51 Inhibitor Cures Chagas’ Disease in a Mouse Model of Acute Infection

Por Doyle, Patricia S., Chen, Chiung-Kuang, Johnston, Jonathan B., Hopkins, Stephanie D., Leung, Siegfried S. F., Jacobson, Matthew P., Engel, Juan C., McKerrow, James H., Podust, Larissa M.
Publicado em 2010

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance()

Por Rand, Arthur C., Leung, Siegfried S. F., Eng, Heather, Rotter, Charles J., Sharma, Raman, Kalgutkar, Amit S., Zhang, Yizhong, Varma, Manthena V., Farley, Kathleen A., Khunte, Bhagyashree, Limberakis, Chris, Price, David A., Liras, Spiros, Mathiowetz, Alan M., Jacobson, Matthew P., Lokey, R. Scott
Publicado em 2012

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Por White, Tina R., Renzelman, Chad M., Rand, Arthur C., Rezai, Taha, McEwen, Cayla M., Gelev, Vladimir M., Turner, Rushia A., Linington, Roger G., Leung, Siegfried S.F., Kalgutkar, Amit S., Bauman, Jonathan N., Zhang, Yizhong, Liras, Spiros, Price, David A., Mathiowetz, Alan M., Jacobson, Matthew P., Lokey, R. Scott
Publicado em 2011

Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target

Por Choy, Jonathan W, Bryant, Clifford, Calvet, Claudia M, Doyle, Patricia S, Gunatilleke, Shamila S, Leung, Siegfried S F, Ang, Kenny K H, Chen, Steven, Gut, Jiri, Oses-Prieto, Juan A, Johnston, Jonathan B, Arkin, Michelle R, Burlingame, Alma L, Taunton, Jack, Jacobson, Matthew P, McKerrow, James M, Podust, Larissa M, Renslo, Adam R
Publicado em 2013