Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance()

A series of cyclic peptides were designed and prepared to investigate the physicochemical properties that affect oral bioavailabilty of this chemotype in rats. In particular, the ionization state of the peptide was examined by the incorporation of naturally occurring amino acid residues that are cha...

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Hlavní autoři: Rand, Arthur C., Leung, Siegfried S. F., Eng, Heather, Rotter, Charles J., Sharma, Raman, Kalgutkar, Amit S., Zhang, Yizhong, Varma, Manthena V., Farley, Kathleen A., Khunte, Bhagyashree, Limberakis, Chris, Price, David A., Liras, Spiros, Mathiowetz, Alan M., Jacobson, Matthew P., Lokey, R. Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488302/
https://ncbi.nlm.nih.gov/pubmed/23133740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD20203D
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