On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

Backbone N-methylation is common among peptide natural products and has a significant impact on both the physical properties and the conformational states of cyclic peptides. However, the specific impact of N-methylation on passive membrane diffusion in cyclic peptides has not been investigated syst...

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Detalhes bibliográficos
Main Authors: White, Tina R., Renzelman, Chad M., Rand, Arthur C., Rezai, Taha, McEwen, Cayla M., Gelev, Vladimir M., Turner, Rushia A., Linington, Roger G., Leung, Siegfried S.F., Kalgutkar, Amit S., Bauman, Jonathan N., Zhang, Yizhong, Liras, Spiros, Price, David A., Mathiowetz, Alan M., Jacobson, Matthew P., Lokey, R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210067/
https://ncbi.nlm.nih.gov/pubmed/21946276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.664
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