Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products

Many cyclic peptide natural products are larger and structurally more complex than conventional small molecule drugs. Although some molecules in this class are known to possess favorable pharmacokinetic properties, there have been few reports on the membrane permeabilities of cyclic peptide natural...

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Bibliographic Details
Published in:Future Med Chem
Main Authors: Ahlbach, Christopher L, Lexa, Katrina W, Bockus, Andrew T, Chen, Valerie, Crews, Phillip, Jacobson, Matthew P, Lokey, R Scott
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5186412/
https://ncbi.nlm.nih.gov/pubmed/26067057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.15.78
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