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Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability

Cyclic octadepsipeptides such as PF1022A and its synthetic derivative emodepside exhibit anthelmintic activity with the latter sold as a commercial drug treatment against gastrointestinal nematodes for animal health use. The structure-permeability relationship of these cyclic depsipeptides that coul...

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Vydáno v:Org Biomol Chem
Hlavní autoři: Stadelmann, Thomas, Subramanian, Govindan, Menon, Sanjay, Townsend, Chad E., Lokey, R. Scott, Ebert, Marc-Olivier, Riniker, Sereina
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7796559/
https://ncbi.nlm.nih.gov/pubmed/32902550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0ob01447h
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